The river runs through it:Naturalising social policy and welfare

This paper reconceptualises social rights through an integration of human welfare and environmental welfare. This is essential if we are making a case for the radical policy changes required to respond to the current environmental crisis, such as maximum living standards and maximum income. As living standards and the demand for social rights increase across the world, this will lead to a concomitant pressure on nature. A maximum living standard based on an ecological footprint is a starting point to think about the need to grant legal rights and resources to nature. Following Polanyi, both humans and the environment are fictitious commodities; we therefore need to rethink our approach to social policy and decommodification to include the environment. This requires approaching social rights from an ecological perspective and breaking the anthropocentric barriers welfare policies create between society and nature. Here, we draw on the work of Michel Serres on the natural contract in order to rethink the content of the social contract and develop an argument in favour of decommodifying nature. Using rivers as legal entities in New Zealand as our example, we illustrate how this theoretical approach could provide the foundations for sustainable eco-social policies in general and maximum living standards in particular

Thermodynamic modeling for numerical simulations based on the generalized cubic equation of state

We further elaborate on the generalized formulation for cubic equation of state proposed by Cismondi and Mollerup [Fluid Phase Equilib. 232 (2005)]. With this formulation all well-known cubic equations of state can be described with a certain pair of values, which allows for a generic implementation of different equations of state. Based on this generalized formulation, we derive a complete thermodynamic model for computational fluid dynamics (CFD) simulations by providing the resulting correlations for all required thermodynamic properties. For the transport properties, we employ the Chung correlations. Our generic implementation includes the often used equations of state Soave-Redlich-Kwong and Peng-Robinson and the Redlich-Kwong-Peng-Robinson (RKPR) equation of state. The first two assume a universal compressibility factor and are therefore only suitable for fluids with a matching critical compressibility. The Redlich-Kwong-Peng-Robinson overcomes this limitation by considering the equation of state parameter as function of the critical compressibility. We compare the resulting thermodynamic modeling for the three equations of state for selected fluids with each other and CoolProp reference data. As supplementary material to this paper, we provide a Python tool called real gas thermodynamic python library (realtpl). This tool can be used to evaluate and compare the results for a wide range of different fluids. Additionally, we also provide the implementation of the generalized form in OpenFOAM

Factors Influencing the Success of In Vivo Sentinel Lymph Node Procedure in Colon Cancer Patients: Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer

Background: The sentinel lymph node (SLN) procedure has the potential to provide relevant improvement in nodal staging in colon cancer patients. However, there remains room for improvement for SLN identification and sensitivity. Therefore, the objective of the present investigation was to analyze factors influencing the success of the SLN procedure in colon cancer patients. Methods: One hundred seventy-four consecutive colon cancer patients were prospectively enrolled in this multicenter study and underwent in vivo SLN procedure with isosulfan blue 1% followed by open standard oncologic colon resection. Several patient-, tumor-, and procedure-related factors possibly influencing the SLN identification and sensitivity were analyzed. Results: Sentinel lymph node identification rate and accuracy were 89.1 and 83.9%, respectively. Successful identification of SLN was significantly associated with the intraoperative visualization of blue lymphatic vessels (p<0.001) and with female gender (p=0.024). True positive SLN results were significantly associated with higher numbers of SLN (p=0.026) and with pN2 stage (p=0.004). There was a trend toward better sensitivity in patients with lower body mass index (BMI) (p=0.050). Conclusions: The success of the SLN procedure in colon cancer patients depends on both procedure-related factors (intraoperative visualization of blue lymphatic vessels, high number of SLN identified) and patient factors (gender, BMI). While patient factors can not be influenced, intraoperative visualization of blue lymphatics and identification of high numbers of SLN are key for a successful SLN procedur

Spin-Peierls instability of the U(1) Dirac spin liquid

Quantum spin liquids are tantalizing phases of frustrated quantum magnets. A complicating factor in their realization and observation in materials is the ubiquitous presence of other degrees of freedom, in particular lattice distortion modes (phonons). These provide additional routes for relieving magnetic frustration, thereby possibly destabilizing spin-liquid ground states. In this work, we focus on triangular-lattice Heisenberg antiferromagnets, where recent numerical evidence suggests the presence of an extended U(1) Dirac spin liquid phase which is described by compact quantum electrodynamics in 2+1 dimensions (QED$_3$), featuring gapless spinons and monopoles as gauge excitations. Its low energy theory is believed to flow to a strongly-coupled fixed point with conformal symmetries. Using complementary perturbation theory and scaling arguments, we show that a symmetry-allowed coupling between (classical) finite-wavevector lattice distortions and monopole operators of the U(1) Dirac spin liquid generally induces a spin-Peierls instability towards a (confining) 12-site valence-bond solid state. We support our theoretical analysis with state-of-the-art density matrix renormalization group simulations. Away from the limit of static distortions, we demonstrate that the phonon energy gap establishes a parameter regime where the spin liquid is expected to be stable.Comment: 23 pages, 10 figure

Guiding climate compatible development: User-orientated analysis of planning tools and methodologies

The focus on climate compatible development (CCD) as an aim for development in a changing climate reflects a growing recognition that mitigation, adaptation and development need to be tackled together, not as separate issues. However, given that CCD is an emergent area of work and study, the availability of guidance resources to assist in bringing the three issues together is limited. This report identifies and analyses the currently available tools and methodologies for adaptation, mitigation and development, in an attempt to guide decision makers towards climate compatible development pathways. Three main research questions are addressed in this report: 1. What tools and methodologies that address climate compatible development or its related aspects currently exist? 2. To what extent do these tools currently satisfy user needs in delivering climate compatible development? 3. Where are there gaps, and what is needed in order to plan climate compatible development? Several findings have emerged from the analysis of the tools: - Many tools have been implemented by users on a ‘do it yourself’ basis, even though the tool developers have built a guided process. - In several categories, the tools are very diverse. For example, in their integration across adaptation, mitigation and development, level of stakeholder involvement, costs, and extent of guidance material. - In a number of categories, the tools are similar in having a high frequency of use and low training requirements. - Most tools apply to the early steps of the policy cycle stages, namely problems identification, assessment of options and selection of policies. Fewer tools assist in the policy implementation and evaluation stages.This study was commissioned by the Climate and Development Knowledge Network (CDKN)

Labeling of mesenchymal stromal cells with iron oxide-poly(l-lactide) nanoparticles for magnetic resonance imaging: uptake, persistence, effects on cellular function and magnetic resonance imaging properties

Background aims. Mesenchymal stromal cells (MSC) are the focus of research in regenerative medicine aiming at the regulatory approval of these cells for specific indications. To cope with the regulatory requirements for somatic cell therapy, novel approaches that do not interfere with the natural behavior of the cells are necessary. In this context in vivo magnetic resonance imaging (MRI) of labeled MSC could be an appropriate tool. Cell labeling for MRI with a variety of different iron oxide preparations is frequently published. However, most publications lack a comprehensive assessment of the noninterference of the contrast agent with the functionality of the labeled MSC, which is a prerequisite for the validity of cell-tracking via MRI. Methods.We studied the effects of iron oxide-poly(L-lactide) nanoparticles in MSC with flow cytom-etry, transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), Prussian blue staining, CyQuant® proliferation testing, colony-forming unit-fibroblast (CFU-F) assays, flow chamber adhesion testing, immuno-logic tests and differentiation tests. Furthermore iron-labeled MSC were studied by MRI in agarose phantoms and Wistar rats. Results. It could be demonstrated that MSC show rapid uptake of nanoparticles and long-lasting intracellular persistence in the endosomal compartment. Labeling of the MSC with these particles has no influence on viability, differentiation, clonogenicity, proliferation, adhesion, phenotype and immunosuppressive properties. They show excellent MRI properties in agarose phantoms and after subcutaneous implantation in rats over several weeks. Conclusions. These particles qualify for studying MSC homing and trafficking via MRI

Characteristics and survival of patients with cancer with intended off-label use-a cohort study.

OBJECTIVE To describe the characteristics and the survival of patients with cancer with intended off-label use (OLU) cancer treatment and reimbursement request. DESIGN Cohort study using medical record data. SETTING Three major cancer centres in Switzerland. PARTICIPANTS 519 patients with cancer and a reimbursement request for OLU between January 2015 and July 2018. MAIN OUTCOMES Characteristics of patients with cancer with and without access to intended OLU. Characteristics included the Glasgow prognostic score (GPS) which includes C reactive protein and albumin and discriminates prognostic groups. RESULTS OLU was intended for 519 (17%) of 3046 patients with cancer, as first-line treatment in 51% (n=264) and second-line in 31% (n=162). Of the 519 patients, 63% (n=328) were male, 63% (n=329) had solid cancer and 21% (n=111) had a haematological malignancy. Their median overall survival was 23.6 months (95% CI: 19.0 to 32.5). Access to OLU had 389 (75%) patients who were compared with patients without access on average 4.9 years younger (mean; 95% CI: 1.9 to 7.9 years), had a better overall prognosis according to the GPS (51% with GPS of 0 vs 39%; OR: 1.62 (95% CI: 1.01 to 2.59)), had less frequently solid cancer (62% vs 71%; OR: 0.66 (95% CI: 0.41 to 1.05)) and advanced stage cancer (53% vs 70%; OR: 0.48 (95% CI: 0.30 to 0.75)), were more frequently treatment-naive (53% vs 43%; OR: 1.55 (95% CI 1.01 to 2.39)) and were more frequently in an adjuvant/neoadjuvant treatment setting (14% vs 5%; OR: 3.39 (95% CI: 1.45 to 9.93)). Patients with access to OLU had a median OS of 31.1 months versus 8.7 months for patients without access (unadjusted HR: 0.54; (95% CI: 0.41 to 0.70)). CONCLUSION Contrary to the common assumption, OLU in oncology is typically not primarily intended for patients with exhausted treatment options. Patient characteristics largely differ between patients with and without access to intended OLU. More systematic evaluations of the benefits and harms of OLU in cancer care and the regulation of its access is warranted

BTDAzo: A Photoswitchable TRPC5 Channel Activator

Photoswitchable reagents can be powerful tools for high-precision biological control. TRPC5 is a Ca2+-permeable cation channel with distinct tissue-specific roles, from synaptic function to hormone regulation. Reagents giving spatiotemporally-resolved control over TRPC5 activity may be key to understanding and harnessing its biology. Here we develop the first photoswitchable TRPC5-modulator, BTDAzo, to address this goal. BTDAzo can photocontrol TRPC5 currents in cell culture, as well as controlling endogenous TRPC5-based neuronal Ca2+ responses in mouse brain slices. BTDAzos are also the first reported azo-benzothiadiazines, an accessible and conveniently derivatised azoheteroarene with strong two-colour photoswitching. BTDAzo ' s ability to control TRPC5 across relevant channel biology settings makes it suitable for a range of dynamically reversible photoswitching studies in TRP channel biology, with the aim to decipher the various biological roles of this centrally important ion channel